Sodium Valproate IP

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Product Description

With rich domain expertise, we have been consistently engaged in providing premium grade Sodium Valproate IP. This valproate is formulated using supreme grade chemical compounds and cutting edge methodology by deft professionals. Offered valproate is extensively demanded in pharmaceutical industry for making medicine used in the treatment of neurological disorder with epilepsy. This Sodium Valproate IP can be purchased from us at remarkable prices.

Quality Key Points:

Non toxic
Stabilize electrical activity
Suitable for both adult and children
High effectiveness

Sodium Valproate IP

We are one of the reliable manufacturers and exporters of finest grade Sodium Valproate IP. Formulated using the latest techniques, this chemical is a sodium salt of valproic acid and is used for treating generalized epilepsy following in accordance to the seizure patters. Offered drug has excellent anti-epileptic and anti-convalsant properties, due to which it is widely used in the preperation of different typoes of drugs. We offer this Sodium Valproate IP to our esteemed clients in different packaging options to cater to their varied requirements at market leading prices.

Pharmacodynamic properties: The exact mode of action is still uncertain but the most likey mode of action is the potentiation of the inhibitory action of gamma amino butyric acid (GABA) through an action on the further synthesis or further metabolism of GABA.

Pharmacokinetic properties:

Protein binding: 90 to 95%
Metabolism: 75% by CYP enzyme
Half life: 9hrs- 18hrs
Excretion: Mainly excreted in urine following metabolism

Indications:

Absence
Myoclonic
Tonic-clonic
Atonic
Mixed

It is also indicated for partial epilepsy:

Simple or complex seizures
Secondary generalized seizures

Pharmacopoeial standards: Our Company has the license to manufacture sodium valproate of following pharmacopoeial standard:

SODIUM VALPROATE BP/SODIUM VALPROATE IP

Product Name	2-propylpentanoic acid, sodium salt
Synonym	Valproic acid, sodium salt
Molecular Formula	C8 H15 Na O2
Molecular Weight	166.2 g / mole
CAS No.	1069-66-5
SPECIFICATIONS
1. Description	A white or almost white crystalline powder, hygroscopic
2. Solubility	Very soluble in water and in ethanol (95%), practically insoluble in ether.
3. Identification	(a) The infra red absorption spectrum is concordant with the reference spectrum of sodium valproate. (b) The retention time of the principal peak in the chromatogram obtained with test solution correspondence to that of the principal peak in the chromatogram obtained with the reference solution. (c) Dence white precipitates is produced indicating test solution gives reaction of sodium salts.
4. Acidity and alkalinity	0.75 ml of either 0.1 M HCl or 0.1 M NaOH required to change the colour of the solution
5. Clarity & colour of the solution	20% w/v solution is not more opalescent than opalescence of reference suspention II and is not more intensely coloured than reference solution Y6
6. Heavy metal	Not more than 20 ppm
7. Chlorides	Not more than 200 ppm
8. Sulphate	Not more than 200 ppm
9. Related substances	(a) Sum of the Total impurities not more than 0.3% (b) Individual impurity not more than 0.1%
10. Loss on drying	Not more than 2.00%
11. Assay (on dry basis)	Between 98.5% to 101% calculated on dry basis.

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