Sodium Valproate BP

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Product Description

We have carved a niche in this domain by offering top grade Sodium Valproate BP. This valproate is formulated using quality examined chemical compounds by our adroit professionals at our advanced processing unit. Provided valproate is extensively used for the treatment of neurological disorder like epilepsy thus highly demanded in pharmaceutical sector. Our precious customers can buy this Sodium Valproate BP from us at rock bottom prices.

Major Product Points:

Longer shelf life
No harmful effects
Adulteration free
Accurate composition

Sodium Valproate BP

Owing to our vast experience of this domain, we are engaged in the manufacturing and exporting of industry grade Sodium Valproate BP. This chemical is a sodium salt of valproic acid, which is Anti-epileptic and Anti-Convalsant in nature. Further, this drug is used for the treatment of generalized epilepsy, in accordance to the seizure patterns. The offered Sodium Valproate BP is formulated precisely in our well equipped firm by our team of dextrous professionals in proper hygienic conditions.

Pharmacodynamic properties: The exact mode of action is still uncertain but the most likely mode of action is the potentiation of the inhibitory action of gamma amino butyric acid (GABA) through an action on the further synthesis or further metabolism of GABA.

Pharmacokinetic properties:

Protein binding: 90 to 95%

Metabolism: 75% by CYP enzyme

Half life: 9hrs- 18hrs

Excretion: Mainly excreted in urine following metabolism.

Indications:

Absence
Myoclonic
Tonic-clonic
Atonic
Mixed

It is also indicated for partial epilepsy:

Simple or complex seizures
Secondary generalized seizures

Pharmacopoeial standards: Our Company has the license to manufacture sodium valproate of following pharmacopoeial standard:

SODIUM VALPROATE BP / SODIUM VALPROATE IP

Product Name	2-propylpentanoic acid, sodium salt
Synonym	Valproic acid, sodium salt
Molecular Formula	C₈ H₁₅Na O₂
Molecular Weight	166.2 g / mole
CAS No.	1069-66-5
SPECIFICATIONS
Description	A white or almost white crystalline powder, hygroscopic
Solubility	Very soluble in water and in ethanol (95%), practically insoluble in ether.
Identification	(a) The infra red absorption spectrum is concordant with the reference spectrum of sodium valproate. (b) The retention time of the principal peak in the chromatogram obtained with test solution correspondence to that of the principal peak in the chromatogram obtained with the reference solution. (c) Dence white precipitates is produced indicating test solution gives reaction of sodium salts.
Acidity and alkalinity	0.75 ml of either 0.1 M HCl or 0.1 M NaOH required to change the color of the solution
Clarity & color of the solution	20% w/v solution is not more opalescent than opalescence of reference suspension II and is not more intensely colored than reference solution Y6
Heavy metal	Not more than 20 ppm
Chlorides	Not more than 200 ppm
Sulphate	Not more than 200 ppm
Related substances	(a) Sum of the Total impurities not more than 0.3% (b) Individual impurity not more than 0.1%
Loss on drying	Not more than 2.00%
Assay (on dry basis)	Between 98.5% to 101% calculated on dry basis.

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