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Sodium Valproate BP

Sodium Valproate BP
Sodium Valproate BP
Product Code : CAS No - 1069-66-5
Product Description

We have carved a niche in this domain by offering top grade Sodium Valproate BP. This valproate is formulated using quality examined chemical compounds by our adroit professionals at our advanced processing unit. Provided valproate is extensively used for the treatment of neurological disorder like epilepsy thus highly demanded in pharmaceutical sector. Our precious customers can buy this Sodium Valproate BP from us at rock bottom prices.


Major Product Points:

  • Longer shelf life
  • No harmful effects
  • Adulteration free
  • Accurate composition

 

 

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Sodium Valproate BP

Owing to our vast experience of this domain, we are engaged in the manufacturing and exporting of industry grade Sodium Valproate BP. This chemical is a sodium salt of valproic acid, which is Anti-epileptic and Anti-Convalsant in nature. Further, this drug is used for the treatment of generalized epilepsy, in accordance to the seizure patterns. The offered Sodium Valproate BP is formulated precisely in our well equipped firm by our team of dextrous professionals in proper hygienic conditions.

Pharmacodynamic properties: The exact mode of action is still uncertain but the most likely mode of action is the potentiation of the inhibitory action of gamma amino butyric acid (GABA) through an action on the further synthesis or further metabolism of GABA.

Pharmacokinetic properties:

Protein binding: 90 to 95%

Metabolism: 75% by CYP enzyme

Half life: 9hrs- 18hrs

Excretion: Mainly excreted in urine following metabolism.

Indications:

  • Absence
  • Myoclonic
  • Tonic-clonic
  • Atonic
  • Mixed

It is also indicated for partial epilepsy:

  • Simple or complex seizures
  • Secondary generalized seizures
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Pharmacopoeial standards: Our Company has the license to manufacture sodium valproate of following pharmacopoeial standard:

                         SODIUM VALPROATE BP      /         SODIUM VALPROATE IP

Product Name

2-propylpentanoic acid, sodium salt

Synonym

Valproic acid, sodium salt

Molecular Formula

C8 H15 Na O2

Molecular Weight

166.2 g / mole

CAS No.

1069-66-5

 

SPECIFICATIONS

 

 

Description

A white or almost white crystalline powder, hygroscopic

Solubility

Very soluble in water and in  ethanol (95%), practically insoluble in ether.

Identification

(a) The infra red absorption  spectrum is concordant with the reference spectrum of sodium valproate. 

(b) The retention time of the principal peak in the chromatogram obtained with test solution correspondence to that of the principal peak in the  chromatogram obtained with the reference solution.

(c) Dence white precipitates is produced indicating test solution gives reaction of sodium salts.

Acidity and alkalinity

0.75 ml of either 0.1 M HCl or 0.1 M NaOH required to change the color of the solution

Clarity & color of the  solution

20% w/v solution is not more opalescent than opalescence of reference suspension II and is not more intensely colored than reference solution Y6 

Heavy metal

Not more than 20 ppm 

Chlorides

Not more than 200 ppm

Sulphate

Not more than 200 ppm

Related substances

(a) Sum of the Total impurities not more than 0.3%

(b) Individual impurity not more than 0.1%

Loss on drying

Not more than 2.00%

Assay (on dry basis)

Between 98.5% to 101% calculated on dry basis.



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ROAQ CHEMICALS PVT. LTD.
41/B-5, GIDC, Estate, Behind Ashok Organics, Nandesari, Vadodara - 391340, Gujarat, India
Phone :+919069140240
Fax :91-265-2780181
Mr. Mukeshchandra Manubhai Patel (Director)
Mobile :+919069140240
Mr. Jaimin Patel
Mobile :+919069140240
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